KLHL21

Across TCGA patient cohorts, KLHL21 mutation is significantly associated with the RNA expression of many other genes, with 267 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL21-associated genes across cancer lineages are MIR6765, RNU4-58P, and RNU6-22P. Each is linked with KLHL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL21-to-partner and partner-to-KLHL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6765 grouped by KLHL21-low versus KLHL21-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL21→partner) and Y-score (partner→KLHL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR6765 →	+0.643	+4.990	<.001	.009	3	2
BLCA	RNU4-58P →	+0.325	+4.106	<.001	.002	3	2
UCEC	RNU6-22P →	+0.251	+2.614	.002	.001	3	2
BLCA	UGT2B24P →	+0.080	+3.478	.005	.005	3	2
UCEC	EIF4E →	+0.512	+3.191	.002	.009	3	1
UCEC	TRIM36 →	+0.950	+3.592	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 267 associations by consensus.

MIR6765 by KLHL21 expression — LUAD

Explore this box plot interactively →