KLHL20

Across TCGA pan-cancer cohorts, KLHL20 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KLHL20 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLHL20 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLHL20 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and GBM are the cancer types where KLHL20 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
UCEC	DFS	Median	II,III,IV	1.000	0.431	.006	36	view →
GBM	OS	Median	All	0.026	0.416	<.001	6	view →
PRAD	DFS	Median	All	0.125	0.774	<.001	6	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	6	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	3	view →
ESCA	DFS	Median	II,III,IV	0.216	0.524	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KLHL20–HNSC (DFS)

Open the HNSC breakdown →