KLHL20

Across TCGA pan-cancer cohorts, KLHL20 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLHL20 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLHL20 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHL20 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where KLHL20 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.866	0.403	.001	33	view →
CCRCC	OS	Median	IV	0.109	0.859	.005	19	view →
LSCC	DFS	Median	III,IV	0.916	0.417	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KLHL20–HNSC (DFS)

Open the HNSC breakdown →