KLHL20

Across TCGA patient cohorts, KLHL20 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL20-associated genes across cancer lineages are Notch1, TFRC, and ATM. Each is linked with KLHL20 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL20-to-partner and partner-to-KLHL20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KLHL20-low versus KLHL20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL20→partner) and Y-score (partner→KLHL20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.222	+2.070	<.001	.001	3	2
UCEC	TFRC →	+0.470	+1.874	.010	.049	3	2
UCEC	ATM →	-0.500	-1.736	.001	.007	3	2
UCEC	Caspase-7-cleavedD198 →	+0.701	+2.341	<.001	.003	3	2
UCEC	4E-BP1 →	+0.303	+1.736	.001	.007	3	2
UCEC	C-Raf →	+0.159	+2.087	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Notch1 by KLHL20 expression — UCEC

Explore this box plot interactively →