KLHL18

Across TCGA patient cohorts, KLHL18 RNA expression is significantly associated with the mutation status of many other genes, with 13,081 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL18-associated genes across cancer lineages are HYDIN, KMT2D, and PEG3. Each is linked with KLHL18 in more than 5 cancer types. Because this analysis shows association rather than direction, both KLHL18-to-partner and partner-to-KLHL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HYDIN grouped by KLHL18-low versus KLHL18-high in UCEC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL18→partner) and Y-score (partner→KLHL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HYDIN →	+1.373	+0.401	<.001	<.001	3	6
SKCM	KMT2D →	+1.573	+0.211	<.001	.002	3	5
UCEC	PEG3 →	+1.415	+0.385	<.001	<.001	3	5
CESC	MUC17 →	+2.822	+0.290	.001	.004	2	5
CESC	DSP →	+3.336	+0.379	.004	.006	3	4
UCEC	ATM →	+1.830	+0.305	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,081 associations by consensus.

HYDIN by KLHL18 expression — UCEC

Explore this box plot interactively →