KLHL18

Across TCGA pan-cancer cohorts, KLHL18 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated KLHL18 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KLHL18 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLHL18 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

ACC, KICH, and UCS are the cancer types where KLHL18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.391	0.776	<.001	92	view →
KICH	DFS	Median	II,III,IV	0.565	0.923	.004	59	view →
UCS	DFS	Median	IV	0.952	0.367	.001	58	view →
MESO	OS	Median	All	0.267	0.507	<.001	55	view →
LIHC	DFS	Median	All	0.464	0.617	<.001	51	view →
SKCM	DFS	Tertile	III,IV	0.436	0.798	<.001	22	view →
SARC	DFS	Median	All	0.206	0.534	<.001	21	view →
LUSC	DFS	Quartile	III,IV	0.206	0.935	.001	19	view →
LUAD	DFS	Quartile	IV	0.522	0.969	.001	18	view →
READ	OS	Quartile	II,III,IV	1.000	0.498	.010	18	view →
GBM	DFS	Tertile	All	0.532	0.239	.001	13	view →
LGG	OS	Quartile	All	0.713	0.900	.007	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

KLHL18–ACC (DFS)

Open the ACC breakdown →