KLHL18

Across TCGA patient cohorts, KLHL18 mutation is significantly associated with the RNA expression of many other genes, with 1,779 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL18-associated genes across cancer lineages are NOP10, CCL4, and RNA5SP411. Each is linked with KLHL18 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL18-to-partner and partner-to-KLHL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOP10 grouped by KLHL18-low versus KLHL18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL18→partner) and Y-score (partner→KLHL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOP10 →	+0.402	+2.628	<.001	<.001	3	3
UCEC	CCL4 →	+1.021	+3.243	<.001	<.001	3	2
UCEC	RNA5SP411 →	+0.742	+1.730	<.001	.001	3	2
UCEC	CCL3 →	+0.909	+2.400	<.001	<.001	3	2
SKCM	MRPL37 →	+0.496	+3.182	.001	.009	3	2
SKCM	GUK1 →	+0.521	+3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,779 associations by consensus.

NOP10 by KLHL18 expression — UCEC

Explore this box plot interactively →