KLHL18

Across TCGA patient cohorts, KLHL18 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL18-associated genes across cancer lineages are ATM, Di-Ras3, and A-Raf_pS299. Each is linked with KLHL18 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL18-to-partner and partner-to-KLHL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KLHL18-low versus KLHL18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL18→partner) and Y-score (partner→KLHL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.593	-2.874	<.001	<.001	3	3
UCEC	Di-Ras3 →	-0.146	-2.571	.005	.010	3	3
UCEC	A-Raf_pS299 →	-0.140	-2.115	<.001	.017	3	2
UCEC	Ku80 →	+0.263	+1.594	.001	.021	3	2
UCEC	MSH6 →	-0.291	-1.874	.012	.049	3	2
UCEC	Shc_pY317 →	-0.163	-2.502	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by KLHL18 expression — UCEC

Explore this box plot interactively →