KLHL18

Across TCGA cell cohorts, KLHL18 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,762 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLHL18-associated GO terms across cancer lineages are Positive regulation of mitotic cell cycle phase transition, rRNA 5'-end processing, and Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with KLHL18 in more than 16 cancer types. Because this analysis shows association rather than direction, both KLHL18-to-partner and partner-to-KLHL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cell cycle phase transition grouped by KLHL18-low versus KLHL18-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL18→partner) and Y-score (partner→KLHL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of mitotic cell cycle phase transition →	+0.105	+0.861	<.001	<.001	2	17
SKIN	rRNA 5'-end processing →	+0.109	+0.807	<.001	<.001	3	14
SKIN	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.109	+0.807	<.001	<.001	3	14
BLOOD_Myeloma	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.107	+0.714	<.001	.004	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell cycle phase transition →	+0.109	+1.232	<.001	<.001	3	14
SOFT_TISSUE	Mitochondrial potassium ion transmembrane transport →	+0.111	+0.827	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,762 associations by consensus.

Positive regulation of mitotic cell cycle phase transition by KLHL18 expression — PANCREAS

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