KLHL18

Across TCGA cell cohorts, KLHL18 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL18-associated genes across cancer lineages are MAGEB18, CGB5, and TEX48. Each is linked with KLHL18 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL18-to-partner and partner-to-KLHL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB18 grouped by KLHL18-low versus KLHL18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL18→partner) and Y-score (partner→KLHL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAGEB18 →	+0.132	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CGB5 →	+0.083	+4.409	<.001	.005	3	1
BLOOD_Leukemia	TEX48 →	+0.047	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1
SKIN	GGTLC2 →	+0.032	+4.273	<.001	.006	3	1
SKIN	OR2G6 →	+0.009	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MAGEB18 by KLHL18 expression — BLOOD_Leukemia

Explore this box plot interactively →