KLHL15

Across TCGA patient cohorts, KLHL15 protein abundance is significantly associated with the RNA expression of many other genes, with 1,124 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLHL15-associated genes across cancer lineages are MSH3, RNA5SP29, and TUBAP8. Each is linked with KLHL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL15-to-partner and partner-to-KLHL15 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL15 versus MSH3 in LSCC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL15→partner) and Y-score (partner→KLHL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MSH3 →	+0.639	+0.548	<.001	.004	3	2
BRCA	RNA5SP29 →	+1.200	+0.602	.003	.008	3	2
LUAD	TUBAP8 →	+0.926	+0.507	.002	<.001	3	2
BRCA	ACP1 →	-0.674	-0.667	.009	.002	3	2
HNSC	RNF125 →	+0.745	+0.560	.004	.009	3	1
HNSC	CNR1 →	+1.555	+0.518	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,124 associations by consensus.

KLHL15 vs MSH3 — LSCC

Explore this scatter interactively →