KLHL11

Across TCGA patient cohorts, KLHL11 mutation is significantly associated with the RNA expression of many other genes, with 1,169 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL11-associated genes across cancer lineages are RPS3AP9, RNU6-1290P, and RNU6-955P. Each is linked with KLHL11 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL11-to-partner and partner-to-KLHL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS3AP9 grouped by KLHL11-low versus KLHL11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL11→partner) and Y-score (partner→KLHL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS3AP9 →	+0.129	+3.407	<.001	.003	3	3
LUAD	RNU6-1290P →	+0.345	+4.712	<.001	.007	3	2
SKCM	RNU6-955P →	+0.159	+5.163	<.001	.002	3	2
CESC	OR6K3 →	+0.164	+5.003	<.001	<.001	3	2
UCEC	PIGUP1 →	+0.200	+1.791	<.001	.003	3	2
UCEC	RBMY2KP →	+0.026	+4.086	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,169 associations by consensus.

RPS3AP9 by KLHL11 expression — COAD

Explore this box plot interactively →