phosphatidylinositol glycan anchor biosynthesis class U pseudogene 1Genealiases: []
Q-omics provides the consensus-scored PIGUP1 profile across patient tissues and cancer cell-line models. PIGUP1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, PIGUP1 is differentially expressed in 8, with the highest sampling consensus in BLCA. Additionally, PIGUP1 RNA expression shows 7,380 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight LGG, BLCA, and THYM as cancer lineages where PIGUP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PIGUP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PIGUP1 survival associations across molecular data types. PIGUP1 RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PIGUP1 RNA expression–survival associations across cancer types. High PIGUP1 expression shows unfavorable associations in LGG, KIRP, UCS and PAAD, but favorable associations in BLCA and SKCM. The LGG Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for PIGUP1 RNA expression.
This table summarizes PIGUP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in BLCA for RNA.
This table ranks reproducible tumor–normal expression differences for PIGUP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PIGUP1 shows higher tumor expression in BLCA, COAD, LUAD, STAD, HNSC and READ. The BLCA box plot shows higher PIGUP1 RNA expression in tumor versus normal tissue (log2 FC = +0.167, t-test p < 0.001).
This table shows molecular features associated with PIGUP1 in patient tissues and cancer cell lines. In patient samples, PIGUP1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
