KLHL10

Across TCGA pan-cancer cohorts, KLHL10 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLHL10 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher KLHL10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL10 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, UCEC, and SKCM are the cancer types where KLHL10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.069	0.688	<.001	18	view →
UCEC	DFS	Median	All	0.956	0.621	.019	18	view →
SKCM	DFS	Median	II,III,IV	0.087	0.708	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KLHL10–BLCA (OS)

Open the BLCA breakdown →