KLHL10

Across TCGA patient cohorts, KLHL10 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL10-associated genes across cancer lineages are EGFR_pY1068, ATM, and Caspase-7-cleavedD198. Each is linked with KLHL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL10-to-partner and partner-to-KLHL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KLHL10-low versus KLHL10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL10→partner) and Y-score (partner→KLHL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.276	-2.502	.005	.002	3	2
UCEC	ATM →	-0.505	-2.502	.004	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.700	+2.604	.002	.005	3	2
UCEC	14-3-3_beta →	-0.084	-3.143	.032	.018	3	1
UCEC	eEF2 →	+0.327	+2.321	.020	.033	3	1
UCEC	eIF4E →	+0.238	+3.584	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR_pY1068 by KLHL10 expression — UCEC

Explore this box plot interactively →