KLHL10

Across TCGA cell cohorts, KLHL10 mutation is significantly associated with the mutation status of many other genes, with 2,614 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL10-associated genes across cancer lineages are ATG9A, ALOXE3, and ZNF516. Each is linked with KLHL10 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL10-to-partner and partner-to-KLHL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATG9A grouped by KLHL10-low versus KLHL10-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL10→partner) and Y-score (partner→KLHL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ATG9A →	+4.392	+4.954	.008	.008	1	4
LUNG_NSCLC_LUAD	ALOXE3 →	+5.339	+4.772	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	ZNF516 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	ST6GALNAC5 →	+5.392	+5.392	.004	.004	1	4
LARGE_INTESTINE	CRTC1 →	+3.087	+4.392	.005	.005	1	4
BLOOD_Leukemia	PKDREJ →	+3.243	+3.762	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,614 associations by consensus.

ATG9A by KLHL10 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →