KLHL1

Across TCGA patient cohorts, KLHL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,952 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLHL1-associated proteins across cancer lineages are RPL7L1, AKAP12_S483, and AKAP12_T1116. Each is linked with KLHL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL1-to-partner and partner-to-KLHL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL1 versus RPL7L1 in PDAC, with a Pearson correlation of -0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL1→partner) and Y-score (partner→KLHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPL7L1 →	-0.411	-0.161	<.001	.001	3	3
GBM	AKAP12_S483 →	+0.915	+0.264	<.001	<.001	3	3
GBM	AKAP12_T1116 →	+0.772	+0.226	<.001	<.001	3	3
GBM	TATDN3 →	+0.261	+0.223	.002	<.001	3	3
GBM	NSF →	+0.666	+0.278	<.001	<.001	3	3
OV	PID1 →	+1.250	+0.285	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,952 associations by consensus.

KLHL1 vs RPL7L1 — PDAC

Explore this scatter interactively →