KLHL1

Across TCGA pan-cancer cohorts, KLHL1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KLHL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where KLHL1 RNA is repressed in tumor relative to normal tissue. In most cancer types KLHL1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and KICH are the cancer types where KLHL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−0.258	<.001	11	view →
KIRC	Male	All	−0.180	<.001	10	view →
KICH	Male	II,III,IV	−0.211	<.001	7	view →
COAD	All	II,III,IV	−0.077	<.001	7	view →
STAD	All	II,III,IV	−0.049	.007	5	view →
BRCA	All	All	+0.474	.001	4	view →
READ	All	All	−0.115	.033	1	view →
LUSC	All	All	+0.008	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

KLHL1–KIRP

Open the KIRP breakdown →