KLHL1

Across TCGA patient cohorts, KLHL1 mutation is significantly associated with the RNA expression of many other genes, with 4,697 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL1-associated genes across cancer lineages are ZWILCH, SAAL1, and SNW1. Each is linked with KLHL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both KLHL1-to-partner and partner-to-KLHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWILCH grouped by KLHL1-low versus KLHL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL1→partner) and Y-score (partner→KLHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWILCH →	+0.524	+2.359	<.001	<.001	3	6
UCEC	SAAL1 →	+0.472	+2.949	<.001	<.001	3	5
UCEC	SNW1 →	+0.355	+2.099	.001	<.001	3	5
STAD	YWHAE →	+0.649	+3.807	<.001	<.001	3	5
UCEC	PROSER1 →	+0.362	+1.818	<.001	.002	3	5
UCEC	GOT2 →	+0.417	+2.222	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,697 associations by consensus.

ZWILCH by KLHL1 expression — UCEC

Explore this box plot interactively →