KLHL1

Across TCGA patient cohorts, KLHL1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL1-associated genes across cancer lineages are Caveolin-1, Bcl-2, and Cyclin-B1. Each is linked with KLHL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL1-to-partner and partner-to-KLHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by KLHL1-low versus KLHL1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL1→partner) and Y-score (partner→KLHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Caveolin-1 →	-0.780	-2.459	.001	<.001	3	4
STAD	Bcl-2 →	-0.216	-3.169	.021	.017	3	3
UCEC	Cyclin-B1 →	+0.645	+3.247	<.001	<.001	3	3
LUSC	p70-S6K →	+0.144	+1.161	.048	.033	3	3
UCEC	ASNS →	+0.288	+1.415	.005	.040	3	3
STAD	FASN →	+0.362	+2.823	.038	.034	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Caveolin-1 by KLHL1 expression — LUAD

Explore this box plot interactively →