KLHL1

Across TCGA cell cohorts, KLHL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 253 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible KLHL1-associated GO terms across cancer lineages are Positive regulation of lipid localization, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, and Behavioral response to pain. Each is linked with KLHL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL1-to-partner and partner-to-KLHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of lipid localization grouped by KLHL1-low versus KLHL1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL1→partner) and Y-score (partner→KLHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of lipid localization →	-0.057	-0.981	.005	.006	3	3
LUNG_SCLC	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.026	+0.793	.007	.008	3	3
LUNG_SCLC	Behavioral response to pain →	-0.217	-0.874	<.001	.009	3	3
SKIN	Vesicle transport along microtubule →	+0.078	+0.006	<.001	.003	3	2
SKIN	Synaptic vesicle transport →	+0.050	+0.004	<.001	.002	3	2
SKIN	Mitochondrion localization →	+0.039	+0.006	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 253 associations by consensus.

Positive regulation of lipid localization by KLHL1 expression — LUNG_SCLC

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