KLHL1

Across TCGA cell cohorts, KLHL1 mutation is significantly associated with the RNA expression of many other genes, with 952 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL1-associated genes across cancer lineages are CNIH1, SUDS3, and TTK. Each is linked with KLHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL1-to-partner and partner-to-KLHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNIH1 grouped by KLHL1-low versus KLHL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL1→partner) and Y-score (partner→KLHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CNIH1 →	+0.404	+3.234	.003	.004	3	2
LARGE_INTESTINE	SUDS3 →	+0.407	+2.596	<.001	.002	3	2
LARGE_INTESTINE	TTK →	+0.472	+1.949	.005	.002	3	2
LARGE_INTESTINE	TTC19 →	+0.702	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	ARL6 →	+0.508	+1.949	<.001	.002	3	2
LARGE_INTESTINE	CEP70 →	+0.833	+3.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 952 associations by consensus.

CNIH1 by KLHL1 expression — LARGE_INTESTINE

Explore this box plot interactively →