Across TCGA pan-cancer cohorts, KLHDC8B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KLHDC8B data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KLHDC8B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLHDC8B expression acts as an unfavorable survival marker.

COAD and LUAD are the cancer types where KLHDC8B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.146	0.874	<.001	22	view →
LUAD	OS	Median	All	0.338	0.834	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: KLHDC8B tumor-vs-normal RNA expression · all KLHDC8B data types