Across TCGA patient cohorts, KLHDC8B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHDC8B-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with KLHDC8B in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC8B-to-partner and partner-to-KLHDC8B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC8B→partner) and Y-score (partner→KLHDC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.582	+3.700	<.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.282	-3.459	.015	.005	3	1
UCEC	ERK2 →	+0.219	+2.321	.014	.034	3	1
UCEC	ETS-1 →	+0.352	+2.999	.017	.035	3	1
UCEC	Gab2 →	+0.361	+2.584	.030	.011	3	1
UCEC	IGFBP2 →	-1.026	-3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

KLHDC8B survival (RNA) · tumor vs normal (RNA) · all KLHDC8B data types