KLHDC8A

Across TCGA patient cohorts, KLHDC8A mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHDC8A-associated genes across cancer lineages are Gab2, Ku80, and MSH2. Each is linked with KLHDC8A in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC8A-to-partner and partner-to-KLHDC8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by KLHDC8A-low versus KLHDC8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC8A→partner) and Y-score (partner→KLHDC8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.421	+2.321	.018	.035	3	1
UCEC	Ku80 →	+0.341	+3.472	.004	.002	3	1
UCEC	MSH2 →	-0.331	-2.973	.004	.035	3	1
UCEC	PKC-a →	+0.412	+2.321	.042	.035	3	1
UCEC	VHL →	-1.240	-3.459	<.001	.005	3	1
UCEC	YB-1_pS102 →	-0.183	-2.321	.049	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Gab2 by KLHDC8A expression — UCEC

Explore this box plot interactively →