KLHDC8A

Across TCGA pan-cancer cohorts, KLHDC8A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KLHDC8A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where KLHDC8A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHDC8A is over-expressed in tumor, although a few such as HNSC and UCEC show the opposite, repressed pattern.

LUAD, KIRC, and THCA are the cancer types where KLHDC8A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHDC8A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+1.419	<.001	11	view →
KIRC	Female	All	+0.928	<.001	11	view →
THCA	Female	III,IV	+5.381	<.001	10	view →
HNSC	Female	All	−1.537	<.001	10	view →
UCEC	All	All	−1.795	.001	6	view →
LUSC	All	All	+0.541	<.001	6	view →
LIHC	Female	All	+0.365	<.001	5	view →
STAD	All	II,III,IV	−0.520	.014	4	view →
CHOL	All	All	+0.800	.001	3	view →
READ	Male	All	+1.013	.028	2	view →
KICH	All	All	−0.410	.019	2	view →
READ	Female	All	−0.530	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KLHDC8A–LUAD

Open the LUAD breakdown →