KLHDC8A

Across TCGA cell cohorts, KLHDC8A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,589 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLHDC8A-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Regulation of syncytium formation by plasma membrane fusion, and Negative regulation of myoblast fusion. Each is linked with KLHDC8A in more than 9 cancer types. Because this analysis shows association rather than direction, both KLHDC8A-to-partner and partner-to-KLHDC8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by KLHDC8A-low versus KLHDC8A-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC8A→partner) and Y-score (partner→KLHDC8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.092	+0.092	<.001	.001	3	10
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.101	+0.192	<.001	.005	2	9
BREAST	Negative regulation of myoblast fusion →	+0.115	+0.190	<.001	.006	3	8
BREAST	Cytoplasmic translation →	+0.082	+0.197	<.001	.002	2	9
BREAST	RNA splicing, via transesterification reactions →	+0.045	+0.177	<.001	.002	3	7
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.053	+1.873	.008	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,589 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by KLHDC8A expression — PANCREAS

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