KLHDC8A

Across TCGA cell cohorts, KLHDC8A mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHDC8A-associated genes across cancer lineages are KRT6C, H2BC1, and H2AC1. Each is linked with KLHDC8A in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC8A-to-partner and partner-to-KLHDC8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT6C grouped by KLHDC8A-low versus KLHDC8A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC8A→partner) and Y-score (partner→KLHDC8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRT6C →	+0.013	+4.930	<.001	.008	3	2
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1
SOFT_TISSUE	IFNA14 →	+0.032	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

KRT6C by KLHDC8A expression — SOFT_TISSUE

Explore this box plot interactively →