KLHDC7B-DT

Across TCGA pan-cancer cohorts, KLHDC7B-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KLHDC7B-DT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLHDC7B-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHDC7B-DT is over-expressed in tumor.

HNSC, KIRC, and THCA are the cancer types where KLHDC7B-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHDC7B-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.934	<.001	12	view →
KIRC	Male	IV	+1.536	<.001	12	view →
THCA	All	II,III,IV	+1.032	<.001	11	view →
LUAD	Female	III,IV	+2.467	<.001	9	view →
BLCA	Male	All	+2.043	<.001	8	view →
KIRP	Male	All	+0.786	<.001	8	view →
STAD	Female	All	+1.934	<.001	7	view →
LIHC	Male	All	+0.715	<.001	7	view →
BRCA	All	All	+1.345	<.001	6	view →
LUSC	Male	All	+1.218	<.001	6	view →
UCEC	All	All	+0.854	.001	6	view →
CHOL	Female	All	+1.503	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KLHDC7B-DT–HNSC

Open the HNSC breakdown →