KLHDC7A

Across TCGA patient cohorts, KLHDC7A mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHDC7A-associated genes across cancer lineages are Caspase-7-cleavedD198, Chk2_pT68, and Di-Ras3. Each is linked with KLHDC7A in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHDC7A-to-partner and partner-to-KLHDC7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KLHDC7A-low versus KLHDC7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC7A→partner) and Y-score (partner→KLHDC7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.474	+1.604	.029	.041	3	3
UCEC	Chk2_pT68 →	-0.175	-3.295	.010	.009	3	3
UCEC	Di-Ras3 →	-0.202	-3.571	<.001	.002	3	3
STAD	beta-Catenin →	+0.691	+3.321	.043	.010	3	2
COAD	Smad1 →	+0.131	+2.347	.043	.019	3	2
COAD	BRCA2 →	+0.277	+3.000	.008	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by KLHDC7A expression — UCEC

Explore this box plot interactively →