KLHDC4

Across TCGA pan-cancer cohorts, KLHDC4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KLHDC4 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KLHDC4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLHDC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, UCEC, and BLCA are the cancer types where KLHDC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.230	0.781	.004	18	view →
UCEC	DFS	Median	All	0.963	0.624	.011	18	view →
BLCA	OS	Median	IV	0.130	0.599	.002	12	view →
OV	DFS	Median	All	0.132	0.541	.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KLHDC4–SKCM (OS)

Open the SKCM breakdown →