KLHDC4

Across TCGA pan-cancer cohorts, KLHDC4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KLHDC4 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLHDC4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLHDC4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where KLHDC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.883	0.979	.013	18	view →
PDAC	DFS	Tertile	II,III,IV	0.656	0.918	.007	6	view →
LSCC	DFS	Quartile	II,III,IV	0.823	0.496	.032	2	view →
LUAD	OS	Quartile	All	1.000	0.894	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KLHDC4–HNSC (DFS)

Open the HNSC breakdown →