KLHDC3

Across TCGA patient cohorts, KLHDC3 mutation is significantly associated with the RNA expression of many other genes, with 902 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHDC3-associated genes across cancer lineages are NEUROD6, IGHD1-14, and ATP5MGP6. Each is linked with KLHDC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC3-to-partner and partner-to-KLHDC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROD6 grouped by KLHDC3-low versus KLHDC3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC3→partner) and Y-score (partner→KLHDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NEUROD6 →	+0.048	+5.812	<.001	.003	3	2
CESC	IGHD1-14 →	+1.419	+5.539	<.001	.004	3	2
LIHC	ATP5MGP6 →	+0.264	+4.567	.001	.004	3	2
CESC	RNU6-625P →	+0.442	+6.342	<.001	.001	3	2
CESC	RN7SL62P →	+0.152	+5.812	<.001	.003	3	2
CESC	FAM8A2P →	+0.056	+5.539	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 902 associations by consensus.

NEUROD6 by KLHDC3 expression — CESC

Explore this box plot interactively →