KLHDC10

Across TCGA patient cohorts, KLHDC10 mutation is significantly associated with the RNA expression of many other genes, with 1,225 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHDC10-associated genes across cancer lineages are YTHDF2, MAN1B1, and NDUFAB1. Each is linked with KLHDC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC10-to-partner and partner-to-KLHDC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YTHDF2 grouped by KLHDC10-low versus KLHDC10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC10→partner) and Y-score (partner→KLHDC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YTHDF2 →	+0.408	+2.818	.005	.001	3	2
UCEC	MAN1B1 →	+0.421	+2.828	.005	.001	3	2
UCEC	NDUFAB1 →	+0.642	+2.860	<.001	.001	3	2
LUAD	OR5AL2P →	+0.053	+6.108	<.001	.001	3	2
UCEC	NDUFAF5 →	+0.405	+2.592	.001	.006	3	2
UCEC	PLEKHJ1 →	+0.755	+3.491	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,225 associations by consensus.

YTHDF2 by KLHDC10 expression — UCEC

Explore this box plot interactively →