Across TCGA patient cohorts, KLHDC1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHDC1-associated genes across cancer lineages are EGFR_pY1068, FASN, and JNK2. Each is linked with KLHDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC1-to-partner and partner-to-KLHDC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC1→partner) and Y-score (partner→KLHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.327	-3.321	.003	.010	3	1
UCEC	FASN →	+0.510	+2.000	.004	.032	3	1
UCEC	JNK2 →	+0.279	+2.700	.001	.006	3	1
UCEC	Ku80 →	+0.452	+3.820	<.001	<.001	3	1
UCEC	Notch1 →	+0.210	+2.000	<.001	.032	3	1
UCEC	N-Ras →	-0.149	-3.150	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

KLHDC1 survival (RNA) · tumor vs normal (RNA) · all KLHDC1 data types