Across TCGA cell cohorts, KLHDC1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHDC1-associated genes across cancer lineages are RAMP3, PTH2R, and RSPO3. Each is linked with KLHDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC1-to-partner and partner-to-KLHDC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC1→partner) and Y-score (partner→KLHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAMP3 →	+0.138	+2.688	<.001	.008	3	1
LARGE_INTESTINE	PTH2R →	+0.732	+3.938	<.001	<.001	3	1
LARGE_INTESTINE	RSPO3 →	+0.061	+2.817	<.001	.007	3	1
LARGE_INTESTINE	ETNPPL →	+0.183	+3.021	.004	.003	3	1
LARGE_INTESTINE	SFTPB →	+0.213	+3.770	<.001	.001	3	1
LARGE_INTESTINE	STARD6 →	+0.080	+3.466	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

KLHDC1 survival (RNA) · tumor vs normal (RNA) · all KLHDC1 data types