KLF9

Across TCGA cell cohorts, KLF9 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,159 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLF9-associated GO terms across cancer lineages are Endoplasmic reticulum mannose trimming, Amyloid-beta clearance by transcytosis, and Positive regulation of excitatory synapse assembly. Each is linked with KLF9 in more than 8 cancer types. Because this analysis shows association rather than direction, both KLF9-to-partner and partner-to-KLF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum mannose trimming grouped by KLF9-low versus KLF9-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF9→partner) and Y-score (partner→KLF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endoplasmic reticulum mannose trimming →	+0.114	+1.724	.004	.008	3	8
SOFT_TISSUE	Amyloid-beta clearance by transcytosis →	+0.137	+1.760	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of excitatory synapse assembly →	-0.904	-1.417	<.001	<.001	3	8
BONE	Collagen metabolic process →	+0.216	+1.331	.001	.005	2	9
SKIN	Golgi vesicle transport →	+0.056	+1.335	<.001	.005	3	8
LUNG_SCLC	Regulation of membrane hyperpolarization →	-0.262	-1.320	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,159 associations by consensus.

Endoplasmic reticulum mannose trimming by KLF9 expression — BONE

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