KLF9

Across TCGA pan-cancer cohorts, KLF9 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of KLF9’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KLF9 RNA is repressed in tumor relative to normal tissue. In most cancer types KLF9 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KIRP are the cancer types where KLF9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−2.458	<.001	11	view →
COAD	Female	All	−2.055	<.001	11	view →
KIRP	All	III,IV	−1.646	<.001	11	view →
THCA	All	II,III,IV	−1.272	<.001	11	view →
KICH	All	III,IV	−2.088	<.001	10	view →
LUSC	All	II,III,IV	−2.148	<.001	8	view →
LUAD	Female	III,IV	−1.528	<.001	8	view →
UCEC	All	All	−2.768	<.001	6	view →
BRCA	Female	All	−1.480	<.001	6	view →
STAD	All	All	−1.170	<.001	5	view →
LIHC	All	All	−0.460	.003	3	view →
KIRC	Male	II,III,IV	−0.443	.025	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

KLF9–BLCA

Open the BLCA breakdown →