KLF8

Across TCGA patient cohorts, KLF8 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,867 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible KLF8-associated proteins across cancer lineages are SEPTIN2, C11orf68, and ISLR. Each is linked with KLF8 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLF8-to-partner and partner-to-KLF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLF8 versus SEPTIN2 in LUAD, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF8→partner) and Y-score (partner→KLF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEPTIN2 →	+0.235	+0.922	<.001	<.001	3	5
BRCA	C11orf68 →	+0.271	+0.753	<.001	.001	3	5
PDAC	ISLR →	+0.648	+0.360	<.001	<.001	3	4
LUAD	LMNA →	+0.450	+0.975	<.001	<.001	3	4
BRCA	LRP1 →	+0.371	+0.912	<.001	<.001	3	4
PDAC	MAP4 →	+0.243	+0.369	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,867 associations by consensus.

KLF8 vs SEPTIN2 — LUAD

Explore this scatter interactively →