KLF7-IT1

Across TCGA pan-cancer cohorts, KLF7-IT1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated KLF7-IT1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KLF7-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLF7-IT1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and BLCA show a favorable association.

KIRP, UVM, and HNSC are the cancer types where KLF7-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.314	0.673	<.001	87	view →
UVM	DFS	Quartile	III,IV	0.125	0.740	.001	48	view →
HNSC	DFS	Tertile	III,IV	0.496	0.766	.006	34	view →
LGG	DFS	Median	All	0.684	0.789	.003	25	view →
COAD	DFS	Quartile	All	0.718	0.867	.007	18	view →
ESCA	OS	Quartile	All	1.000	0.445	.009	18	view →
LIHC	OS	Tertile	All	0.613	0.763	.004	18	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	13	view →
BLCA	DFS	Median	IV	0.321	0.151	.017	13	view →
LUAD	OS	Median	III,IV	0.803	0.511	.004	12	view →
LAML	DFS	Median	All	0.590	0.355	.029	12	view →
CHOL	OS	Quartile	II,III,IV	0.351	0.935	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

KLF7-IT1–KIRP (DFS)

Open the KIRP breakdown →