KLF7-IT1

Across TCGA pan-cancer cohorts, KLF7-IT1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KLF7-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where KLF7-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types KLF7-IT1 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

BRCA, BLCA, and STAD are the cancer types where KLF7-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF7-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.593	<.001	6	view →
BLCA	All	All	−0.482	.012	4	view →
STAD	All	All	−0.181	.032	4	view →
LUSC	Male	All	−0.246	.006	3	view →
THCA	All	All	−0.237	.002	3	view →
UCEC	All	All	−0.247	.014	2	view →
COAD	All	All	+0.159	.022	2	view →
KIRP	Male	All	−0.209	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

KLF7-IT1–BRCA

Open the BRCA breakdown →