KLF6

Across TCGA patient cohorts, KLF6 mutation is significantly associated with the RNA expression of many other genes, with 756 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF6-associated genes across cancer lineages are RNU6-591P, OR6F1, and RNA5SP161. Each is linked with KLF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLF6-to-partner and partner-to-KLF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-591P grouped by KLF6-low versus KLF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF6→partner) and Y-score (partner→KLF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-591P →	+0.120	+4.896	<.001	.001	3	3
LUAD	OR6F1 →	+0.081	+5.631	<.001	.004	3	2
UCEC	RNA5SP161 →	+0.901	+1.943	<.001	.002	3	2
LUAD	OR6L1P →	+0.204	+5.798	<.001	.003	3	2
LUAD	TIMM8BP1 →	+0.709	+5.984	<.001	.002	3	2
LUAD	NANOGP3 →	+0.248	+7.599	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 756 associations by consensus.

RNU6-591P by KLF6 expression — UCEC

Explore this box plot interactively →