KLF6

Across TCGA pan-cancer cohorts, KLF6 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KLF6’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KLF6 RNA is repressed in tumor relative to normal tissue. In most cancer types KLF6 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and UCEC are the cancer types where KLF6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−1.477	<.001	11	view →
COAD	Female	All	−0.879	<.001	9	view →
UCEC	All	IV	−3.439	<.001	8	view →
KICH	Female	All	−1.739	<.001	8	view →
LUAD	Female	II,III,IV	−1.576	<.001	8	view →
LUSC	Female	II,III,IV	−1.878	<.001	7	view →
BRCA	All	III,IV	−1.417	<.001	6	view →
LIHC	All	All	−0.657	.001	5	view →
THCA	Female	All	−1.432	<.001	4	view →
KIRC	Male	All	+0.701	<.001	3	view →
READ	All	All	−1.047	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KLF6–BLCA

Open the BLCA breakdown →