KLF6

Across TCGA patient cohorts, KLF6 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF6-associated genes across cancer lineages are GSK-3a-b_pS21_S9, JNK2, and NF2. Each is linked with KLF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF6-to-partner and partner-to-KLF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by KLF6-low versus KLF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF6→partner) and Y-score (partner→KLF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.467	+2.594	.009	.006	3	1
UCEC	JNK2 →	+0.246	+2.196	.003	.032	3	1
UCEC	NF2 →	+0.261	+3.169	.004	.018	3	1
UCEC	N-Ras →	-0.139	-3.439	.005	.005	3	1
UCEC	Akt_pT308 →	+0.540	+3.321	.043	.009	3	1
UCEC	P-Cadherin →	-0.135	-2.999	.027	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

GSK-3a-b_pS21_S9 by KLF6 expression — UCEC

Explore this box plot interactively →