KLF6

Across TCGA cell cohorts, KLF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,950 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible KLF6-associated GO terms across cancer lineages are Actin filament depolymerization, Regulation of focal adhesion assembly, and Regulation of cell-substrate junction assembly. Each is linked with KLF6 in more than 14 cancer types. Because this analysis shows association rather than direction, both KLF6-to-partner and partner-to-KLF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by KLF6-low versus KLF6-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF6→partner) and Y-score (partner→KLF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Actin filament depolymerization →	+0.227	+1.643	<.001	<.001	3	15
BONE	Regulation of focal adhesion assembly →	+0.123	+1.119	<.001	.004	3	14
BONE	Regulation of cell-substrate junction assembly →	+0.123	+1.119	<.001	.004	3	14
BLOOD_Myeloma	Negative regulation of monocyte chemotaxis →	+1.137	+1.518	<.001	.001	3	14
BREAST	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.152	+1.616	.003	.001	2	14
KIDNEY	MAPK cascade →	+0.068	+1.437	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,950 associations by consensus.

Actin filament depolymerization by KLF6 expression — LIVER

Explore this box plot interactively →