KLF5

Across TCGA patient cohorts, KLF5 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,716 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLF5-associated proteins across cancer lineages are ARHGEF6_S225, TTLL12, and TBC1D9_S471. Each is linked with KLF5 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLF5-to-partner and partner-to-KLF5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLF5 versus ARHGEF6_S225 in UCEC, with a Pearson correlation of -0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF5→partner) and Y-score (partner→KLF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGEF6_S225 →	-0.570	-0.729	<.001	.005	3	5
LSCC	TTLL12 →	+0.496	+1.511	<.001	<.001	3	4
BRCA	TBC1D9_S471 →	-0.761	-0.990	<.001	<.001	3	4
UCEC	C6orf132 →	+0.511	+0.619	<.001	<.001	3	4
LUAD	CCDC88A →	-0.233	-0.673	<.001	<.001	3	4
LUAD	CDR2_S311 →	-0.417	-0.734	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,716 associations by consensus.

KLF5 vs ARHGEF6_S225 — UCEC

Explore this scatter interactively →