KLF5

Across TCGA pan-cancer cohorts, KLF5 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KLF5 data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher KLF5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KLF5 expression acts as an unfavorable survival marker, although some lineages such as LUSC and KIRC show a favorable association.

LUSC, LUAD, and KIRP are the cancer types where KLF5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.483	0.279	<.001	66	view →
LUAD	DFS	Tertile	All	0.746	0.862	<.001	60	view →
KIRP	OS	Tertile	II,III,IV	0.670	0.923	.013	51	view →
PAAD	OS	Median	All	0.284	0.521	.001	49	view →
KIRC	OS	Median	All	0.718	0.550	<.001	47	view →
CESC	OS	Quartile	II,III,IV	0.969	0.722	.001	38	view →
SKCM	OS	Tertile	All	0.277	0.429	<.001	35	view →
ACC	DFS	Tertile	All	0.149	0.644	.001	34	view →
UCS	DFS	Tertile	IV	0.885	0.250	.024	24	view →
COAD	OS	Median	IV	0.568	0.339	.019	24	view →
MESO	DFS	Tertile	III,IV	0.526	0.287	.010	16	view →
READ	DFS	Tertile	IV	0.383	0.805	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KLF5–LUSC (DFS)

Open the LUSC breakdown →