KLF5

Across TCGA patient cohorts, KLF5 protein abundance is significantly associated with the RNA expression of many other genes, with 19,426 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLF5-associated genes across cancer lineages are IFFO1, JAK3, and ARSB. Each is linked with KLF5 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLF5-to-partner and partner-to-KLF5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLF5 versus IFFO1 in OV, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF5→partner) and Y-score (partner→KLF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IFFO1 →	-0.888	-0.554	.001	.006	3	4
LSCC	JAK3 →	-0.867	-0.633	<.001	<.001	3	4
OV	ARSB →	-0.748	-0.530	<.001	.003	3	4
OV	WIPF1 →	-1.064	-0.669	<.001	<.001	3	4
LSCC	LY9 →	-0.716	-0.535	<.001	<.001	3	4
HNSC	ARHGAP9 →	-0.861	-0.500	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,426 associations by consensus.

KLF5 vs IFFO1 — OV

Explore this scatter interactively →