KLF5

Across TCGA patient cohorts, KLF5 mutation is significantly associated with the RNA expression of many other genes, with 2,795 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF5-associated genes across cancer lineages are URM1, ECI1, and HEXIM2. Each is linked with KLF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF5-to-partner and partner-to-KLF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, URM1 grouped by KLF5-low versus KLF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF5→partner) and Y-score (partner→KLF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	URM1 →	+0.375	+3.708	.004	<.001	3	2
UCEC	ECI1 →	+0.550	+3.609	.001	.001	3	2
UCEC	HEXIM2 →	+0.436	+3.616	.002	.001	3	2
UCEC	ZDHHC14 →	-0.577	-3.584	.001	.002	3	2
UCEC	TRO →	-1.015	-2.404	.005	.003	3	2
UCEC	CCDC163 →	+0.492	+3.130	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,795 associations by consensus.

URM1 by KLF5 expression — UCEC

Explore this box plot interactively →