KLF5

Across TCGA cell cohorts, KLF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,245 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLF5-associated GO terms across cancer lineages are Response to endothelin, Cellular response to endothelin, and Cellular response to calcium ion starvation. Each is linked with KLF5 in more than 12 cancer types. Because this analysis shows association rather than direction, both KLF5-to-partner and partner-to-KLF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endothelin grouped by KLF5-low versus KLF5-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF5→partner) and Y-score (partner→KLF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to endothelin →	+0.246	+1.730	.007	<.001	3	13
LUNG_SCLC	Cellular response to endothelin →	+0.194	+1.587	.004	<.001	3	13
BONE	Cellular response to calcium ion starvation →	+0.254	+2.125	<.001	<.001	3	12
LUNG_NSCLC_LUSC	AMPA glutamate receptor clustering →	-1.227	-2.455	.001	.003	3	11
LUNG_NSCLC_LUSC	Glutamate receptor clustering →	-1.227	-2.455	.001	.003	3	11
LIVER	Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.153	+2.560	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,245 associations by consensus.

Response to endothelin by KLF5 expression — LUNG_SCLC

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